Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation

@article{Yang2019CarbazoleAF,
  title={Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation},
  author={J. Yang and Xin-Yi Wang and Yiping Zhou and Rong Lu and Chin-Ho Chen and M. Zhang and Yung-Yi Cheng and S. Morris-Natschke and K. Lee and Yun-Song Wang},
  journal={Molecules},
  year={2019},
  volume={25}
}
Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3–8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1–8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1NL4-3 Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC50 value of 2.4 μg/mL and SI of 7.1. 
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