Carbapenem-resistant Escherichia coli and Klebsiella pneumoniae isolates from Turkey with OXA-48-like carbapenemases and outer membrane protein loss.

@article{Glmez2008CarbapenemresistantEC,
  title={Carbapenem-resistant Escherichia coli and Klebsiella pneumoniae isolates from Turkey with OXA-48-like carbapenemases and outer membrane protein loss.},
  author={Dolunay G{\"u}lmez and Neil Woodford and M F I Palepou and Shazad Mushtaq and Gokhan Metan and Yusuf Yakupoğullari and Sesin Kocagoz and Omrum Uzun and Gulsen Hascelik and David Martin Livermore},
  journal={International journal of antimicrobial agents},
  year={2008},
  volume={31 6},
  pages={523-6}
}
Treatment options are limited in infections caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae, with carbapenems generally preferred. Disturbingly, however, carbapenem-resistant strains are emerging worldwide. Here we report two clinical isolates, one Escherichia coli and one Klebsiella pneumoniae, each with high-level carbapenem resistance (imipenem minimum inhibitory concentration of 32 microg/mL). They were isolated following imipenem therapy from two hospital… CONTINUE READING

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