Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology.

@article{Poirel2006CarbapenemRI,
  title={Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology.},
  author={Laurent Poirel and Patrice Nordmann},
  journal={Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases},
  year={2006},
  volume={12 9},
  pages={
          826-36
        }
}
  • L. Poirel, P. Nordmann
  • Published 2006
  • Biology, Medicine
  • Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
The increasing trend of carbapenem resistance in Acinetobacter baumannii worldwide is a concern since it limits drastically the range of therapeutic alternatives. Metallo-beta-lactamases (VIM, IMP, SIM) have been reported worldwide, especially in Asia and western Europe, and confer resistance to all beta-lactams except aztreonam. The most widespread beta-lactamases with carbapenemase activity in A. baumannii are carbapenem-hydrolysing class D beta-lactamases (CHDLs) that are mostly specific for… Expand
OXA beta-lactamase-mediated carbapenem resistance in Acinetobacter baumannii.
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The presence of OXA carbapenamases and coproduction of metallo-beta-lactamases (blaVIM and blaIMP ) by phenotypic and genotypic methods incarbapenem resistant clinical isolates of Acinetobacter baumannii was detected. Expand
Diversity of plasmid-mediated carbapenem-hydrolysing oxacillinases among carbapenem-resistant Acinetobacter baumannii isolates from Kingdom of Bahrain.
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TLDR
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Overexpression of the Naturally Occurring blaOXA-51 Gene in Acinetobacter baumannii Mediated by Novel Insertion Sequence ISAba9
TLDR
Despite a weak catalytic activity, the naturally occurring OXA-51/69-type β-lactamases might contribute to carbapenem resistance by insertion of ISAba1 in the promoter region of the blaOXA-53-like genes, as observed with ISAbA1 in A. baumannii strains tested. Expand
A plethora of carbapenem resistance in Acinetobacter baumannii: no end to a long insidious genetic journey
TLDR
Though Colistin is considered as the most promising antibacterial agent, nevertheless faces adverse effects flaws, Cefiderocol, eravacycline, new β-lactam antibiotics, non-β- lactam- β-Lactamase inhibitors, polymyxin B-derived molecules and bacteriophages are some other new treatment options streamlined. Expand
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