Carbamylation of serum albumin and erythropoietin resistance in end stage kidney disease.

@article{Kalim2013CarbamylationOS,
  title={Carbamylation of serum albumin and erythropoietin resistance in end stage kidney disease.},
  author={Sahir Kalim and Hector Tamez and Julia B. Wenger and Elizabeth D Ankers and Caitlin A. Trottier and Joseph J. Deferio and Anders Hayden Berg and Siddharth Karumanchi and Ravi I. Thadhani},
  journal={Clinical journal of the American Society of Nephrology : CJASN},
  year={2013},
  volume={8 11},
  pages={1927-34}
}
BACKGROUND AND OBJECTIVES The mechanisms underlying erythropoietin resistance are not fully understood. Carbamylation is a post-translational protein modification that can alter the function of proteins, such as erythropoietin. The hypothesis of this study is that carbamylation burden is independently associated with erythropoietin resistance. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS In a nonconcurrent prospective cohort study of incident hemodialysis patients in the United States… CONTINUE READING