Carbamylated erythropoietin protects the kidneys from ischemia-reperfusion injury without stimulating erythropoiesis.

@article{Imamura2007CarbamylatedEP,
  title={Carbamylated erythropoietin protects the kidneys from ischemia-reperfusion injury without stimulating erythropoiesis.},
  author={Ryoichi Imamura and Yoshitaka Isaka and Naotsugu Ichimaru and Shiro Takahara and Akihiko Okuyama},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={353 3},
  pages={786-92}
}
Several studies have shown that erythropoietin (EPO) can protect the kidneys from ischemia-reperfusion injury and can raise the hemoglobin (Hb) concentration. Recently, the EPO molecule modified by carbamylation (CEPO) has been identified and was demonstrated to be able to protect several organs without increasing the Hb concentration. We hypothesized that treatment with CEPO would protect the kidneys from tubular apoptosis and inhibit subsequent tubulointerstitial injury without erythropoiesis… CONTINUE READING
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