Carbamazepine reduces short-interval interhemispheric inhibition in healthy humans

  title={Carbamazepine reduces short-interval interhemispheric inhibition in healthy humans},
  author={Martin Sommer and Elena Gileles and Kathrin Knappmeyer and Holger Rothkegel and Walter Paulus},
  journal={Clinical Neurophysiology},
OBJECTIVE We sought to elucidate the influence of centrally active drugs on interhemispheric inhibition (IHI) between primary motor cortices in healthy humans. METHODS We therefore studied IHI before and 2h after intake of a single oral dose of carbamazepine, dextrometorphane, lorazepam, or placebo and compared it with the well known results for short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF). Drugs were tested in separate sessions and in random order… CONTINUE READING

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