Carbamazepine is an inhibitor of histone deacetylases.

  title={Carbamazepine is an inhibitor of histone deacetylases.},
  author={Andreas S. Beutler and Side Li and Rebekka Nicol and Martin J. Walsh},
  journal={Life sciences},
  volume={76 26},
Carbamazepine (CBZ) is a common antiepileptic drug (AED) that acts through multiple mechanisms including blockade and potentiation of cation channels and modulation of neurotransmitter levels. Whether it affects any component of the gene transcription machinery is unknown. Histone deacetylases (HDAC) are important in the regulation of gene expression and are currently considered a potential target for drug development. Using a high-throughput screening assay based on acetylation-dependent gene… CONTINUE READING