Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy

  title={Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy},
  author={Sebasti{\~a}o Sousa Almeida and Maria da Graça Naffah-Mazzacoratti and Paola Bianchi Guimar{\~a}es and Frederick Wasinski and Frances E. Pereira and Mauro Canzian and Ricardo da Silva Centeno and Henrique H. Carrete and Elza M.T. Yacubian and Adriana Karaoglanovich Carmona and Renata de Freitas Fischer Vieira and Cl{\'o}vis Ryuichi Nakaie and Regiane Ang{\'e}lica Sabatini and Sandra Regina Perosa and Reury Frank Pereira Bacurau and Telma Luciana Furtado Gouveia and Guillermo Gallo and Martin W{\"u}rtele and Esper Abr{\~a}o Cavalheiro and Julia de Almeida Silva and Jo{\~a}o Bosco Pesquero and Ronaldo C Araujo},
  booktitle={Translational Psychiatry},
We find that a common mutation that increases angiotensin I-converting enzyme activity occurs with higher frequency in male patients suffering from refractory temporal lobe epilepsy. However, in their brains, the activity of the enzyme is downregulated. As an explanation, we surprisingly find that carbamazepine, commonly used to treat epilepsy, is an inhibitor of the enzyme, thus providing a direct link between epilepsy and the renin–angiotensin and kallikrein–kinin systems. 
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