Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan.

  title={Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan.},
  author={Pei Chen and Juei-Jueng Lin and C. S. Lu and Cheung-Ter Ong and Peiyuan F. Hsieh and Chih-Chao Yang and Chih-Ta Tai and S Wu and Cheng-Hsien Lu and Yung-Chu Hsu and H Y Yu and L S Ro and Chung-Ta Lu and C Chu and Jing-Jane Tsai and Yu-Hsiang Su and Sheng-Hsing Lan and Sheng-Feng Sung and Shu-yi Lin and Hui-Ping Chuang and Li-Chen Huang and Ying-ju Chen and Pei-Joung Tsai and Hung-Ting Liao and Y Lin and Chien-Hsiun Chen and Wen-Hung Chung and Shuen-Iu Hung and J Wu and Chi-Feng Chang and Luke Chen and Yuan-Tsong Chen and Chen-yang Shen},
  journal={The New England journal of medicine},
  volume={364 12},
BACKGROUND Carbamazepine, an anticonvulsant and a mood-stabilizing drug, is the main cause of the Stevens-Johnson syndrome (SJS) and its related disease, toxic epidermal necrolysis (TEN), in Southeast Asian countries. Carbamazepine-induced SJS-TEN is strongly associated with the HLA-B*1502 allele. We sought to prevent carbamazepine-induced SJS-TEN by using HLA-B*1502 screening to prospectively identify subjects at genetic risk for the condition. METHODS From 23 hospitals in Taiwan, we… CONTINUE READING
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The role of HLA-B*1502 in carbamazepine-induced Stevens-Johnson syndrome

  • CY Wei, HW Huang, YT Chen, SI. Hung
  • Programs and abstracts of the TaiwanACGA 2010…
  • 2010

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