Carbamazepine increases extracellular serotonin concentration: lack of antagonism by tetrodotoxin or zero Ca2+.

@article{Dailey1997CarbamazepineIE,
  title={Carbamazepine increases extracellular serotonin concentration: lack of antagonism by tetrodotoxin or zero Ca2+.},
  author={John W. Dailey and Maarten E. A. Reith and Qing Shan Yan and Min Li and Phillip C. Jobe},
  journal={European journal of pharmacology},
  year={1997},
  volume={328 2-3},
  pages={153-62}
}
Carbamazepine administration causes large increases in extracellular serotonin concentration and dose-related anticonvulsant effects in genetically epilepsy-prone rats (GEPRs). In order to determine the generality of the effect on serotonin, we determined the anticonvulsant ED50 for carbamazepine against maximal electroshock seizures in outbred, non-epileptic Sprague-Dawley rats. We then administered anticonvulsant carbamazepine doses to Sprague-Dawley rats and observed extracellular serotonin… CONTINUE READING
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