Carbamazepine in the treatment of cocaine dependence: subtyping by affective disorder.


Studies investigating carbamazepine (CBZ) in the treatment of cocaine dependence have been inconsistent. In this study, cocaine-dependent individuals with (n = 57) and without (n = 82) affective disorder were compared in a 12-week, double-blind, placebo-controlled trial. Urine drug screens (UDS) and self-report of drug use were collected weekly. Affective symptoms were measured monthly. Subjects receiving CBZ attended more medication sessions (p = .03). The CBZ-treated affective group had a trend toward fewer cocaine-positive UDS (p = .08) and a significantly longer time to first cocaine use (p = .06). CBZ treatment did not have any impact on cocaine use in individuals without affective disorders.


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@article{Brady2002CarbamazepineIT, title={Carbamazepine in the treatment of cocaine dependence: subtyping by affective disorder.}, author={Kathleen T. Brady and Susan C. Sonne and Robert J. Malcolm and Carrie L. Randall and Bonnie S Dansky and Kit N. Simpson and J. Steven Roberts and Michael J Brondino}, journal={Experimental and clinical psychopharmacology}, year={2002}, volume={10 3}, pages={276-85} }