Carbamazepine and phenytoin induced Stevens‐Johnson syndrome is associated with HLA‐B*1502 allele in Thai population

@article{Locharernkul2008CarbamazepineAP,
  title={Carbamazepine and phenytoin induced Stevens‐Johnson syndrome is associated with HLA‐B*1502 allele in Thai population},
  author={Chaichon Locharernkul and Jakrin Loplumlert and Chusak Limotai and Wiwat Korkij and Tayard Desudchit and Siraprapa Tongkobpetch and Oratai Kangwanshiratada and Nattiya Hirankarn and Kanya Suphapeetiporn and Vorasuk Shotelersuk},
  journal={Epilepsia},
  year={2008},
  volume={49}
}
Purpose:  Previous studies found a strong association between HLA‐B*1502 and carbamazepine (CBZ)‐induced Stevens‐Johnson syndrome (SJS) in Han Chinese, but not in Caucasian populations. Even in Han Chinese, the HLA‐B*1502 was not associated with CBZ‐induced maculopapular eruptions (MPE). This study seeks to identify whether HLA‐B*1502 is associated with CBZ‐ or phenytoin (PHT)‐induced SJS or MPE in a Thai population. 
HLA‐B*1502 Strongly Predicts Carbamazepine‐Induced Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis in Thai Patients with Neuropathic Pain
Background:  Carbamazepine (CBZ) is one of the standard pharmacological treatments for neuropathic pain. However, its serious adverse drug reactions include Stevens–Johnson syndrome (SJS) and toxic
Association between HLA‐B*1502 and carbamazepine‐induced severe cutaneous adverse drug reactions in a Thai population
TLDR
Results from this study suggest that HLA‐B*1502 may be a useful pharmacogenetic test for screening Thai individuals who may be at risk for CBZ‐induced SJS and TEN.
HLA‐B alleles associated with severe cutaneous reactions to antiepileptic drugs in Han Chinese
HLA‐B*15:02 screening is recommended before starting carbamazepine in Han Chinese and Southeast Asians because the allele is strongly predictive of Stevens‐Johnson syndrome (SJS)/toxic epidermal
The association of HLA B*15:02 allele and Stevens–Johnson syndrome/toxic epidermal necrolysis induced by aromatic anticonvulsant drugs in a South Indian population
  • K. Devi
  • Medicine
    International journal of dermatology
  • 2018
The presence of HLA‐B*15:02 allele is considered a risk factor for development of Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in patients taking aromatic anticonvulsant drugs like
Association of HLA‐B*1502 allele with lamotrigine‐induced Stevens–Johnson syndrome and toxic epidermal necrolysis in Han Chinese subjects: a meta‐analysis
Despite several studies investigating the association between the human leukocyte antigen HLA‐B*1502 allele and lamotrigine‐induced Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)
Phenytoin-induced Stevens–Johnson syndrome with negative HLA-B*1502 allele in mainland China: Two cases
TLDR
Evidence is provided to support that other genetic markers or nongenetic factors could contribute to the susceptibility of PHT-induced SJS, except for HLA-B*1502 allele, and to investigate the genetic link with P HT-induced serious skin reactions in future.
Association between HLA and Stevens–Johnson Syndrome Induced by Carbamazepine in Southern Han Chinese: Genetic Markers besides B*1502?
TLDR
Given the association between HLA‐B*1502 and CBZ‐induced SJS/TEN, genetic testing before initiating CBZ therapy is suggested in Han Chinese population, and physicians should also be vigilant about SJS /TEN in those negative for HLA•B* 1502.
HLA Class I markers in Japanese patients with carbamazepine‐induced cutaneous adverse reactions
TLDR
Examination of HLA class I in Japanese patients with severe cADRs may suggest that HLA‐B*5901 is one of the candidate markers for CBZ‐induced SJS in Japanese, which is reported recently that the human leukocyte antigen HLA*1502 is associated with Stevens‐Johnson syndrome in Han Chinese.
HLA‐B*1511 is a risk factor for carbamazepine‐induced Stevens‐Johnson syndrome and toxic epidermal necrolysis in Japanese patients
TLDR
The genotyped the HLA‐B locus from 14 Japanese typical and atypical SJS/TEN patients in whom carbamazepine was considered to be involved in the onset of adverse reactions and suggested that HLA·B*1511, a member of HLA•B75, is a risk factor for carbamazepsine‐induced SJS /TEN in Japanese.
Investigating the association of Lamotrigine and Phenytoin‐induced Stevens‐Johnson syndrome/Toxic Epidermal Necrolysis with HLA‐B*1502 in Iranian population
TLDR
Lamotrigine‐induced SJS/TEN is associated with HLA‐B*1502 allele in an Iranian population but this is not the case for phenytoin‐induced TEN.
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