Carbamazepine Does Not Alter Biochemical Parameters of Bone Turnover in Healthy Male Adults

Carbamazepine Does Not Alter Biochemical Parameters of Bone Turnover in Healthy Male Adults
  author={S. Br{\"a}mswig and Armin Zittermann and Heiner K. Berthold},
  journal={Calcified Tissue International},
It is still not completely clear whether or not carbamazepine (CBZ) causes alterations in vitamin D status and in bone metabolism. The objective of this study was therefore to investigate prospectively in healthy adults the effects of CBZ on serum levels of 25-hydroxyvitamin D (25OHD) and on biomarkers of bone formation and resorption. Twenty-one free-living male adults were taking 800 mg/day CBZ for 10 weeks. The study was performed from December 1997 until September 1998 at a geographic… 

Bone density and bone turnover markers in patients with epilepsy on chronic antiepileptic drug therapy.

Patients on AED demonstrate reduced BMD among the AED, phenobarbital seems to be the main mediator of low BMD and increases in CTX-I.

Bone health in young women with epilepsy after one year of antiepileptic drug monotherapy

In women receiving phenytoin, lower serum 25-hydroxyvitamin D concentrations were associated with higher parathyroid hormone, bone alkaline phosphatase, and urine N-telopeptide levels, a biochemical pattern consistent with secondary hyperparathyroidism and increased remodeling.

Bone mineral density following long-term use of antiepileptic drugs in a tropical Asian country.

There was found to be no significant correlation between age, sex, body mass index, duration of treatment and type of antiepileptic drug with bone mineral density at the femur and spine in Thai epileptics who had been receiving long-term, antiePileptic drugs.

A systematic review of vitamin D status in populations worldwide

Examination of patterns of 25-hydroxyvitamin D levels worldwide and differences by age, sex and region suggested that newborns and institutionalised elderly from several regions worldwide appeared to be at a generally higher risk of exhibiting lower 25(OH)D values.

Epilepsy and bone health in adults

Antiepileptic drugs and bone disease

Several mechanisms for AED-associated bone disease have been proposed, but no single mechanisms adequately addresses all the reported findings.

Effect of carbamazepine on the bone health of people with epilepsy: a systematic review and meta-analysis

Evidence is provided that CBZ treatment has a negative effect on bone health in PWE with skeletal diseases or osteoporosis, and clinical implications are that long-termCBZ treatment may not be a good choice for people with epilepsy with skeletal illnesses.

Vitamin D Levels and Bone Turnover in Epilepsy Patients Taking Carbamazepine or Oxcarbazepine

Evidence suggests that enzyme‐inducing antiepileptic drugs (AEDs) may decrease serum 25‐hydroxyvitamin D levels and increase bone turnover and seek to determine whether these are affected by treatment with carbamazepine or oxcarbazepine.



Long-term anticonvulsant therapy and vitamin D metabolism in ambulatory pubertal children.

Routine vitamin D supplementation does not appear to be indicated in children on anticonvulsant therapy, and parameters of calcium metabolism were thoroughly examined, indicating that anticonVulsant drugs alter significantly the vitamin D metabolism.

Seasonal variations in vitamin D status and calcium absorption do not influence bone turnover in young women

The data indicate a decrease in intestinal calcium and phosphorus absorption during wintertime, most likely because of a reduction in serum 25OHD levels.

Increased bone turnover in epileptic patients treated with carbamazepine

It is demonstrated that carbamazepine induces an increase of bone turnover and higher values of markers of bone formation and of bone resorption are found in patients than in controls.

Nitrogen metabolism and bone metabolism markers in healthy adults during 16 weeks of bed rest.

Bone formation decreases rapidly during immobilization in parallel with a higher renal excretion of intestinally absorbed calcium, and changes appear in association with the onset of a negative nitrogen balance, but decreased bone collagen synthesis and enhanced collagen breakdown occur after a time lag of several weeks.

Markers of bone remodeling in the elderly subject: Effects of vitamin D insufficiency and its correction

  • M. BrazierS. Kamel J. Sebert
  • Medicine, Biology
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 1995
Most markers of bone remodeling are increased in elderly subjects with vitamin D insufficiency and vary with its correction, however, BAP and DPD are the most sensitive indicators of increased bone turnover due to secondary hyperparathyroidism.

Analysis of the musculoskeletal system in children and adolescents receiving anticonvulsant monotherapy with valproic acid or carbamazepine.

Bone turnover can be increased, but bone mass is adequate in children and adolescents who have uncomplicated idiopathic epilepsy and who receive monotherapy with carbamazepine or valproic acid.

Changes in Bone Turnover Induced by Aerobic and Anaerobic Exercise in Young Males

  • H. WoitgeB. Friedmann M. Seibel
  • Biology, Medicine
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 1998
While aerobic training led to changes compatible with reduced bone resorption activity, anaerobic training seems to result in an overall accelerated bone turnover, suggesting the impact of physical activity on bone turnover may depend on the kind of exercise performed.

The vitamin D status of man at 70° north

Despite the sun being below the horizon for two of the winter months, the 25-OHD-concentration remained at a constant and fairly high level (50-55 nmol/l).

Antiepileptic drug-induced bone loss in young male patients who have seizures.

Long-term AED therapy in young male patients who have seizures causes significant bone loss at the hip in the absence of vitamin D deficiency, and dual-energy x-ray absorptiometry scanning of the hip is useful in identifying patients who are particularly susceptible to rapid bone loss while taking AEDs.

Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D.

All age groups exhibit a high prevalence of 25(OH)D insufficiency and secondary hyperparathyroidism, and older adults are just as efficient in maintaining 25( OH)D, but they need more vitamin D to produce the higher vitamin D concentrations required to overcome the hyperparathiroidism associated with their diminishing renal function.