Carbamazepine‐Induced Release of Serotonin from Rat Hippocampus In Vitro

  title={Carbamazepine‐Induced Release of Serotonin from Rat Hippocampus In Vitro},
  author={John W. Dailey and Maarten E. A. Reith and Kevin R. Steidley and Joseph C. Milbrandt and Phillip C. Jobe},
Summary: Purpose: Carbamazepine is one of several antiepileptic drugs (AEDs) that release the inhibitory neurotransmitter serotonin as part of their pharmacodynamic action on brain neurons. We undertook this study to investigate the cellular processes by which carbamazepine (CBZ) releases serotonin from brain tissue. 

The Effect of Antiepileptic Drugs on 5‐HT1A–Receptor Binding Measured by Positron Emission Tomography

5‐HT1A–receptor binding, measured by positron emission tomography, is reduced in patients with temporal lobe epilepsy, and antiepileptic drugs may act on the serotonergic system, and thus affect receptor‐binding measurements.

Shared Mechanisms of Antidepressant and Antiepileptic Treatments: Drugs and Devices

  • P. Jobe
  • Psychology, Biology
    Clinical EEG and neuroscience
  • 2004
Increasing evidence supports the hypothesis that noradrenergic and/or serotonergic elevation is a mechanism of therapeutic benefit shared by most antidepressants and many antiepileptic medications.

Fatal Serotonin Syndrome Precipitated by Oxcarbazepine in a Patient Using an Selective Serotonin Reuptake Inhibitor

This is the first reported fatality due to this drug interaction and only the second case of serotonin syndrome reported with oxcarbazepine, and Physicians should consider this risk when prescribing the above combination.

High resolution micro‐SPECT scanning in rats using 125I β‐CIT: Effects of chronic treatment with carbamazepine

Purpose:  Carbamazepine (CBZ) is a first‐line antiepileptic agent with mood‐stabilizing effects in bipolar disorder. It has been reported to influence extracellular concentrations of serotonin and

Bipolar Disorders and Carbamazepine: Pharmacokinetics,Pharmacodynamics, Therapeutic Effects and Indications of Carbamazepine: Review of Articles

Carbamazepine is a mood stabilizer which is approved for use in bipolar disorder with manic and mixed episodes and for the treatment of trigeminal neuralgia, temporal lobe epilepsy and generalized tonic-clonic seizure.

Interaction of pregabalin with carbamazepine in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves.

  • J. Luszczki
  • Biology, Medicine
    Advances in medical sciences
  • 2010
The additive interaction between PGB and CBZ is worthy of consideration while extrapolating the results from this study to clinical settings, and neither motor coordination, long-term memory nor muscular strength were affected.

Effect of carbamazepine on tetrodotoxin-resistant Na+ channels in trigeminal ganglion neurons innervating to the dura

The present results suggest that carbamazepine may be useful for the treatment of migraine headaches.



Carbamazepine and Zonisamide Increase Extracellular Dopamine and Serotonin Levels In Vivo, and Carbamazepine Does Not Antagonize Adenosine Effect In Vitro: Mechanisms of Blockade of Seizure Spread

The object of this paper is to study the common mechanisms of action for both drugs by which a seizure spread is blocked as the understanding of such mechanism of action may shed some light on the pathogenesis of secondary generalization of seizures.

The Role of Neurotransmitters in Electroshock Seizure Models

The purpose of this report is to examine the evidence that specific neurotransmitters play a modulatory role in the susceptibility to and/or the expression of electrically induced experimental

Effects of fluoxetine on convulsions and on brain serotonin as detected by microdialysis in genetically epilepsy-prone rats.

It is concluded that fluoxetine is an effective anticonvulsant in GEPRs and that the microdialysis results strongly suggest a relationship between the effects of fluoxettine on serotonergic neurons and the anticonVulsant effect produced by this drug.