Carbamazepine‐Induced Release of Serotonin from Rat Hippocampus In Vitro

@article{Dailey1998CarbamazepineInducedRO,
  title={Carbamazepine‐Induced Release of Serotonin from Rat Hippocampus In Vitro},
  author={John W. Dailey and Maarten E. A. Reith and Kevin R. Steidley and Joseph C. Milbrandt and Philip C. Jobe},
  journal={Epilepsia},
  year={1998},
  volume={39}
}
Summary: Purpose: Carbamazepine is one of several antiepileptic drugs (AEDs) that release the inhibitory neurotransmitter serotonin as part of their pharmacodynamic action on brain neurons. We undertook this study to investigate the cellular processes by which carbamazepine (CBZ) releases serotonin from brain tissue. 

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The additive interaction between PGB and CBZ is worthy of consideration while extrapolating the results from this study to clinical settings, and neither motor coordination, long-term memory nor muscular strength were affected.

Effect of carbamazepine on tetrodotoxin-resistant Na+ channels in trigeminal ganglion neurons innervating to the dura

The present results suggest that carbamazepine may be useful for the treatment of migraine headaches.
...

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