Carbamazepine‐Induced Release of Serotonin from Rat Hippocampus In Vitro

@article{Dailey1998CarbamazepineInducedRO,
  title={Carbamazepine‐Induced Release of Serotonin from Rat Hippocampus In Vitro},
  author={John W. Dailey and Maarten E. A. Reith and Kevin R. Steidley and Joseph C. Milbrandt and P. C. Jobe},
  journal={Epilepsia},
  year={1998},
  volume={39}
}
Summary: Purpose: Carbamazepine is one of several antiepileptic drugs (AEDs) that release the inhibitory neurotransmitter serotonin as part of their pharmacodynamic action on brain neurons. We undertook this study to investigate the cellular processes by which carbamazepine (CBZ) releases serotonin from brain tissue. 
The Effect of Antiepileptic Drugs on 5‐HT1A–Receptor Binding Measured by Positron Emission Tomography
TLDR
5‐HT1A–receptor binding, measured by positron emission tomography, is reduced in patients with temporal lobe epilepsy, and antiepileptic drugs may act on the serotonergic system, and thus affect receptor‐binding measurements. Expand
Shared Mechanisms of Antidepressant and Antiepileptic Treatments: Drugs and Devices
  • P. Jobe
  • Medicine
  • Clinical EEG and neuroscience
  • 2004
TLDR
Increasing evidence supports the hypothesis that noradrenergic and/or serotonergic elevation is a mechanism of therapeutic benefit shared by most antidepressants and many antiepileptic medications. Expand
Should antidepressant drugs of the selective serotonin reuptake inhibitor family be tested as antiepileptic drugs?
TLDR
Preclinical and clinical data are reviewed to address the question of whether there is enough evidence that would support a randomized placebo-controlled trial to test antiepileptic effect of SSRIs in PWE. Expand
Fatal Serotonin Syndrome Precipitated by Oxcarbazepine in a Patient Using an Selective Serotonin Reuptake Inhibitor
TLDR
This is the first reported fatality due to this drug interaction and only the second case of serotonin syndrome reported with oxcarbazepine, and Physicians should consider this risk when prescribing the above combination. Expand
Lamotrigine, carbamazepine and phenytoin differentially alter extracellular levels of 5-hydroxytryptamine, dopamine and amino acids
TLDR
The effects of the anticonvulsants lamotrigine, phenytoin and carbamazepine and CBZ on basal and stimulated extracellular aspartate, glutamate, GLU and ASP in the hippocampus of freely moving rats using microdialysis suggest that there are marked differences in the neurochemical mechanisms of antiepileptic drug action. Expand
High resolution micro‐SPECT scanning in rats using 125I β‐CIT: Effects of chronic treatment with carbamazepine
Purpose:  Carbamazepine (CBZ) is a first‐line antiepileptic agent with mood‐stabilizing effects in bipolar disorder. It has been reported to influence extracellular concentrations of serotonin andExpand
Bipolar Disorders and Carbamazepine: Pharmacokinetics,Pharmacodynamics, Therapeutic Effects and Indications of Carbamazepine: Review of Articles
TLDR
Carbamazepine is a mood stabilizer which is approved for use in bipolar disorder with manic and mixed episodes and for the treatment of trigeminal neuralgia, temporal lobe epilepsy and generalized tonic-clonic seizure. Expand
Carbamazepine pharmacokinetics-pharmacodynamics in genetically epilepsy-prone rats.
TLDR
In a concentration-controlled design using intracerebral microdialysis, hippocampal carbamazepine infusions produced similar concentration-response relations for the three rat strains, supporting the hypothesis that dose-response differences among the threeRat strains are primarily pharmacokinetic in nature. Expand
Interaction of pregabalin with carbamazepine in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves.
TLDR
The additive interaction between PGB and CBZ is worthy of consideration while extrapolating the results from this study to clinical settings, and neither motor coordination, long-term memory nor muscular strength were affected. Expand
Effect of carbamazepine on tetrodotoxin-resistant Na+ channels in trigeminal ganglion neurons innervating to the dura
TLDR
The present results suggest that carbamazepine may be useful for the treatment of migraine headaches. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 45 REFERENCES
Carbamazepine and Zonisamide Increase Extracellular Dopamine and Serotonin Levels In Vivo, and Carbamazepine Does Not Antagonize Adenosine Effect In Vitro: Mechanisms of Blockade of Seizure Spread
TLDR
The object of this paper is to study the common mechanisms of action for both drugs by which a seizure spread is blocked as the understanding of such mechanism of action may shed some light on the pathogenesis of secondary generalization of seizures. Expand
Anticonvulsant doses of carbamazepine increase hippocampal extracellular serotonin in genetically epilepsy-prone rats: dose response relationships
TLDR
It is determined that carbamazepine produces a dose related increase in extracellular serotonin in each of the two GEPR strains, providing further support for the hypothesis that release of serotonin by carbamazepsine is an important part of the pharmacodynamic action by which this drug suppresses seizures. Expand
Anticonvulsant effect of intranigral fluoxetine
TLDR
The data suggest that serotonergic transmission inSN exerts a seizure suppressing action which is independent of GABA transmission in SN. Expand
The Role of Neurotransmitters in Electroshock Seizure Models
The purpose of this report is to examine the evidence that specific neurotransmitters play a modulatory role in the susceptibility to and/or the expression of electrically induced experimentalExpand
Carbamazepine increases extracellular serotonin concentration: lack of antagonism by tetrodotoxin or zero Ca2+.
TLDR
The findings suggest that the serotonin releasing effect of carbamazepine does not take place by exocytosis and does not require action potentials in the brain area in which the release takes place, and suggests that the effect is mediated by an action of carbsepine directly on serotonergic nerve terminals. Expand
Effects of zonisamide on extracellular levels of monoamine and its metabolite, and on Ca2+ ependent dopamine release
TLDR
The present results suggest that zonisamide facilitates dopaminergic and serotoninergic neurotransmission but does not affect Ca2+ dependent dopamine release within therapeutic plasma concentrations. Expand
Effects of fluoxetine on convulsions and on brain serotonin as detected by microdialysis in genetically epilepsy-prone rats.
TLDR
It is concluded that fluoxetine is an effective anticonvulsant in GEPRs and that the microdialysis results strongly suggest a relationship between the effects of fluoxettine on serotonergic neurons and the anticonVulsant effect produced by this drug. Expand
The effect of valproic acid on 5-hydroxytryptamine and 5-hydroxyindoleacetic acid concentration in hippocampal dialysates in vivo.
TLDR
Valproate caused a dose-dependent increase in dialysate 5-HT, but in contrast no effect on 5-HIAA level was observed, considered with regard to a possible role of 5- HT in mediating the anticonvulsant action of valproate. Expand
Evidence that a serotonergic mechanism is involved in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats.
TLDR
It is suggested that a serotonergic mechanism is involved in the anticonvulsant effects of fluoxetine in GEPRs, and a combination of these two drugs with 5-HTP or 5-Hydroxytryptophan resulted in decreased audiogenic seizure intensity. Expand
The anticonvulsant effect of the broad spectrum anticonvulsant loreclezole may be mediated in part by serotonin in rats: a microdialysis study
TLDR
It is concluded that loreclezole produces a dose-related anticonVulsant effect in GEPRs and that anticonvulsant doses of lorecleZole increase extracellular serotonin in these animals. Expand
...
1
2
3
4
5
...