Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase.

@article{Darvesh2008CarbamatesWD,
  title={Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase.},
  author={Sultan Darvesh and Katherine V Darvesh and Robert S McDonald and Diane Mataija and Ryan Walsh and Sam Mothana and Oksana Lockridge and Earl Martin},
  journal={Journal of medicinal chemistry},
  year={2008},
  volume={51 14},
  pages={4200-12}
}
Most carbamates are pseudoirreversible inhibitors of cholinesterases. Phenothiazine carbamates exhibit this inhibition of acetylcholinesterase but produce reversible inhibition of butyrylcholinesterase, suggesting that they do not form a covalent bond with the catalytic serine. This atypical inhibition is attributable to pi-pi interaction of the… CONTINUE READING