Carbacyclic peptide mimetics as VCAM-VLA-4 antagonists.

Abstract

Substitution of carbon for sulfur in a potent 13-membered cyclic disulfide containing peptide was accomplished via an intramolecular Wittig reaction and resulted in a series of 'carba' analogues. Potency in the VCAM-VLA-4 assay was sensitive to ring size and lower than that of the parent disulfide. 

Topics

  • Presentations referencing similar topics