CarD integrates three functional modules to promote efficient transcription, antibiotic tolerance, and pathogenesis in mycobacteria.

@article{Garner2014CarDIT,
  title={CarD integrates three functional modules to promote efficient transcription, antibiotic tolerance, and pathogenesis in mycobacteria.},
  author={Ashley L. Garner and Leslie A. Weiss and Ana Ruiz Manzano and Eric A Galburt and Christina L Stallings},
  journal={Molecular microbiology},
  year={2014},
  volume={93 4},
  pages={682-97}
}
Although the basic mechanisms of prokaryotic transcription are conserved, it has become evident that some bacteria require additional factors to allow for efficient gene transcription. CarD is an RNA polymerase (RNAP)-binding protein conserved in numerous bacterial species and essential in mycobacteria. Despite the importance of CarD, its function at transcription complexes remains unclear. We have generated a panel of mutations that individually target three independent functional modules of… CONTINUE READING
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