Capturing the essence of folding and functions of biomolecules using coarse-grained models.

@article{Hyeon2011CapturingTE,
  title={Capturing the essence of folding and functions of biomolecules using coarse-grained models.},
  author={Changbong Hyeon and D Thirumalai},
  journal={Nature communications},
  year={2011},
  volume={2},
  pages={487}
}
The distances over which biological molecules and their complexes can function range from a few nanometres, in the case of folded structures, to millimetres, for example, during chromosome organization. Describing phenomena that cover such diverse length, and also time, scales requires models that capture the underlying physics for the particular length scale of interest. Theoretical ideas, in particular, concepts from polymer physics, have guided the development of coarse-grained models to… CONTINUE READING
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