Capturing the Dynamics of a Spring-Loaded Protein.


Skp and other holdase chaperones bind unfolded bacterial outer membrane proteins, preventing premature folding until they insert into the membrane. In this issue of Structure, Holdbrook et al. (2017) use a combination of NMR, SAXS, ensemble optimization, and MD simulations to show that the Skp chaperone samples a much wider range of conformations than… (More)
DOI: 10.1016/j.str.2017.06.008


Cite this paper

@article{Mitchell2017CapturingTD, title={Capturing the Dynamics of a Spring-Loaded Protein.}, author={Joshua A Mitchell and Megan L. O'Mara}, journal={Structure}, year={2017}, volume={25 7}, pages={963-964} }