Capturing Human Naïve Pluripotency in the Embryo and in the Dish.

@article{Zimmerlin2017CapturingHN,
  title={Capturing Human Na{\"i}ve Pluripotency in the Embryo and in the Dish.},
  author={Ludovic Zimmerlin and Tea Soon Park and Elias T. Zambidis},
  journal={Stem cells and development},
  year={2017},
  volume={26 16},
  pages={
          1141-1161
        }
}
Although human embryonic stem cells (hESCs) were first derived almost 20 years ago, it was only recently acknowledged that they share closer molecular and functional identity to postimplantation lineage-primed murine epiblast stem cells than to naïve preimplantation inner cell mass-derived mouse ESCs (mESCs). A myriad of transcriptional, epigenetic, biochemical, and metabolic attributes have now been described that distinguish naïve and primed pluripotent states in both rodents and humans… CONTINUE READING

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