Capturing Chromosome Conformation

  title={Capturing Chromosome Conformation},
  author={J. Dekker and K. Rippe and Martijn K. Dekker and N. Kleckner},
  pages={1306 - 1311}
  • J. Dekker, K. Rippe, +1 author N. Kleckner
  • Published 2002
  • Biology, Medicine
  • Science
  • We describe an approach to detect the frequency of interaction between any two genomic loci. Generation of a matrix of interaction frequencies between sites on the same or different chromosomes reveals their relative spatial disposition and provides information about the physical properties of the chromatin fiber. This methodology can be applied to the spatial organization of entire genomes in organisms from bacteria to human. Using the yeast Saccharomyces cerevisiae, we could confirm known… CONTINUE READING
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