Capturing Chromosome Conformation
@article{Dekker2002CapturingCC, title={Capturing Chromosome Conformation}, author={J. Dekker and K. Rippe and Martijn K. Dekker and N. Kleckner}, journal={Science}, year={2002}, volume={295}, pages={1306 - 1311} }
We describe an approach to detect the frequency of interaction between any two genomic loci. Generation of a matrix of interaction frequencies between sites on the same or different chromosomes reveals their relative spatial disposition and provides information about the physical properties of the chromatin fiber. This methodology can be applied to the spatial organization of entire genomes in organisms from bacteria to human. Using the yeast Saccharomyces cerevisiae, we could confirm known… CONTINUE READING
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References
SHOWING 1-10 OF 37 REFERENCES
Collisions between yeast chromosomal loci in vivo are governed by three layers of organization.
- Biology, Medicine
- Genes & development
- 1999
- 92
- PDF
Regional base composition variation along yeast chromosome III: evolution of chromosome primary structure.
- Biology, Medicine
- Nucleic acids research
- 1993
- 114
Clustering of meiotic double-strand breaks on yeast chromosome III.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1997
- 344
- PDF
Cohesins Bind to Preferential Sites along Yeast Chromosome III, with Differential Regulation along Arms versus the Centric Region
- Biology, Medicine
- Cell
- 1999
- 411
- PDF
Meiotic chromosomes: integrating structure and function.
- Biology, Medicine
- Annual review of genetics
- 1999
- 1,097
Chromosomal Addresses of the Cohesin Component Mcd1p
- Biology, Medicine
- The Journal of cell biology
- 2000
- 238
- PDF
Polymer models for interphase chromosomes.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1993
- 56
- PDF
Chromatin organization at meiosis
- Biology, Medicine
- BioEssays : news and reviews in molecular, cellular and developmental biology
- 1988
- 105
Chromosome bands, their chromatin flavors, and their functional features.
- Biology, Medicine
- American journal of human genetics
- 1992
- 329