Capture of recombinant ricin A chain by a bispecific anti-RTA: anti-CEA monoclonal antibody pre-targeted to a human gastric carcinoma xenograft in nude mice

Abstract

A bispecific antibody against carcinoembryonic antigen (CEA) and ricin A chain has been shown to localise in a CEA-producing human tumour xenograft. When labelled recombinant ricin A chain was subsequently injected there was uptake into tumours, indicating that this bispecific antibody can capture or carry toxin into tumour deposits.

DOI: 10.1007/BF01294441

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Cite this paper

@article{Pimm1992CaptureOR, title={Capture of recombinant ricin A chain by a bispecific anti-RTA: anti-CEA monoclonal antibody pre-targeted to a human gastric carcinoma xenograft in nude mice}, author={Malcolm V. Pimm and Richard A Robins and Robert W. Baldwin}, journal={Journal of Cancer Research and Clinical Oncology}, year={1992}, volume={118}, pages={367-370} }