Capture of plasma membrane fragments from target cells by trogocytosis requires signaling in T cells but not in B cells.

@article{Aucher2008CaptureOP,
  title={Capture of plasma membrane fragments from target cells by trogocytosis requires signaling in T cells but not in B cells.},
  author={Anne Aucher and Eddy Magdeleine and Etienne Joly and Denis Hudrisier},
  journal={Blood},
  year={2008},
  volume={111 12},
  pages={5621-8}
}
Upon recognition of their respective cellular partners, T and B cells acquire their antigens by a process of membrane capture called trogocytosis. Here, we report that various inhibitors of actin polymerization or of kinases involved in intracellular signaling partially or fully inhibited trogocytosis by CD8(+) and CD4(+) T cells, whereas they had no effect on trogocytosis by B cells. Similarly, trogocytosis by T cells was inhibited at 4 degrees C, whereas in B cells it was independent of… CONTINUE READING