Capture of Neuroepithelial-Like Stem Cells from Pluripotent Stem Cells Provides a Versatile System for In Vitro Production of Human Neurons

@inproceedings{Falk2012CaptureON,
  title={Capture of Neuroepithelial-Like Stem Cells from Pluripotent Stem Cells Provides a Versatile System for In Vitro Production of Human Neurons},
  author={Anna Helena Falk and Philipp Koch and Jaideep C. Kesavan and Yasuhiro Takashima and Julia Ladewig and Michael Alexander and Ole Wiskow and Jignesh Tailor and Matthew W. Trotter and Steven M Pollard and Austin G. Smith and Oliver Bruestle},
  booktitle={PloS one},
  year={2012}
}
Human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) provide new prospects for studying human neurodevelopment and modeling neurological disease. In particular, iPSC-derived neural cells permit a direct comparison of disease-relevant molecular pathways in neurons and glia derived from patients and healthy individuals. A prerequisite for such comparative studies are robust protocols that efficiently yield standardized populations of neural cell types. Here we show that… CONTINUE READING
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Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency.

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