Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci

Abstract

Multiple regulatory elements distant from their targets on the linear genome can influence the expression of a single gene through chromatin looping. Chromosome conformation capture implemented in Hi-C allows for genome-wide agnostic characterization of chromatin contacts. However, detection of functional enhancer-promoter interactions is precluded by its… (More)
DOI: 10.1038/ncomms7178

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