Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23

@inproceedings{McGovern2016CaptureHI,
  title={Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23},
  author={Amanda McGovern and Stefan Schoenfelder and Paul Martin and Jonathan Massey and Kate Duffus and Darren Plant and Annie Yarwood and Arthur G. Pratt and Amy E Anderson and John Dudley Isaacs and Julie Diboll and Nishanthi Thalayasingam and Caroline Ospelt and Anne Barton and Jane Worthington and Peter Fraser and Stephen Eyre and Gisela Orozco},
  booktitle={Genome Biology},
  year={2016}
}
The identification of causal genes from genome-wide association studies (GWAS) is the next important step for the translation of genetic findings into biologically meaningful mechanisms of disease and potential therapeutic targets. Using novel chromatin interaction detection techniques and allele specific assays in T and B cell lines, we provide compelling evidence that redefines causal genes at the 6q23 locus, one of the most important loci that confers autoimmunity risk. Although the function… CONTINUE READING
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