Captopril suppresses inflammation in endotoxin-induced uveitis in rats.

  title={Captopril suppresses inflammation in endotoxin-induced uveitis in rats.},
  author={Iliyana Bozhidarova Ilieva and Kazuhiro Ohgami and Xue-hai Jin and Yukari Suzuki and Kenji Shiratori and Kazuhiko Yoshida and Satoru Kase and Shigeaki Ohno},
  journal={Experimental eye research},
  volume={83 3},
Captopril is an inhibitor of angiotensin-converting enzyme (ACE) that is largely used in the treatment of cardiovascular diseases. Several previous studies have demonstrated that captopril exhibits a wide variety of biological activities, including an anti-inflammatory action, on which we focused our attention. The aim of the present study was to investigate the efficacy of captopril on endotoxin induced uveitis (EIU) in rats. We investigated its effect upon cellular infiltration and protein… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 57 references

Function and activation of NF-kappa B in the immune system.

Annual review of immunology • 1994
View 17 Excerpts
Highly Influenced

Activation and suppression of renin-angiotensin system in human dendritic cells.

Biochemical and biophysical research communications • 2002
View 9 Excerpts
Highly Influenced

Suppression of ocular inflammation in endotoxin-induced uveitis by blocking the angiotensin II type 1 receptor.

Investigative ophthalmology & visual science • 2005
View 3 Excerpts
Highly Influenced

Angiotensin II and reactive oxygen species.

Antioxidants & redox signaling • 2005
View 1 Excerpt

Inhibition of matrix metalloproteinase activity and growth of gastric adenocarcinoma cells by an angiotensin converting enzyme inhibitor in in vitro and murine models.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology • 2005
View 2 Excerpts

The effect of angiotensin-converting enzyme inhibitors on experimental colitis in rats

N Jahovich, F Ercan, +3 authors I Alican
Regul Pept, • 2005