Captopril reduces the severity of bowel damage in a neonatal rat model of necrotizing enterocolitis.


BACKGROUND/PURPOSE Selective mesenteric ischemia may result from activation of the renin-angiotensin system during periods of shock and is implicated in the pathogenesis of neonatal necrotizing enterocolitis (NEC). We investigated the effectiveness of captopril, an angiotensin-converting enzyme inhibitor, in reducing the severity of bowel damage in a… (More)
DOI: 10.1016/j.jpedsurg.2007.10.022