Captopril reduces collagen and mast cell accumulation in irradiated rat lung.

@article{Ward1990CaptoprilRC,
  title={Captopril reduces collagen and mast cell accumulation in irradiated rat lung.},
  author={William F. Ward and Agostino Molteni and Chung hsin Ts'ao and Joann M. Hinz},
  journal={International journal of radiation oncology, biology, physics},
  year={1990},
  volume={19 6},
  pages={
          1405-9
        }
}
  • W. Ward, A. Molteni, +1 author J. Hinz
  • Published 1990
  • Medicine
  • International journal of radiation oncology, biology, physics
The angiotensin converting enzyme inhibitor captopril ameliorates radiation-induced pulmonary endothelial dysfunction in rats. The present study determined whether captopril also reduces collagen (hydroxyproline) accumulation in the lungs of rats sacrificed 2 months after a range of single doses (0-30 Gy) of 60Co gamma rays to the right hemithorax. Captopril was administered in the feed at a regimen of 0, 25, or 50 mg/kg/day continuously after irradiation. Mast cell counts also were obtained… Expand
Radioprotective effect of captopril on the mouse jejunal mucosa.
TLDR
The results suggest that captopril provides protection from acute radiation damage to the jejunal mucosa in mice. Expand
Radiation pneumonitis in rats and its modification by the angiotensin-converting enzyme inhibitor captopril evaluated by high-resolution computed tomography.
TLDR
It is demonstrated that high-resolution CT can detect radiation reactions in rat lung within 4 weeks after 60 Gy/10 fractions, and that captopril spares these acute changes detected by CT. Expand
Effect of captopril on changes in rats' hearts induced by long-term irradiation.
TLDR
The results showed that captopril, while ameliorating the decrease in the indices of capillary function, increase in mast cells, fibrosis, number of atrial granules, and changes in nerve terminals, failed to prevent the progressive functional deterioration of the hearts after irradiation. Expand
Captopril Inhibits Proliferation of Human Lung Fibroblasts in Culture: A Potential Antifibrotic Mechanism
  • L. Nguyen, W. Ward, C. Ts'ao, A. Molteni
  • Chemistry, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1994
TLDR
The antifibrotic activity of captopril in irradiated lung may result in part from a direct inhibition of fibroblast proliferation, particularly in fibroblasts responding to mitogenic stimuli. Expand
Angiotensin converting enzyme inhibitor captopril does not prevent acute gastrointestinal radiation damage in the rat.
TLDR
Retrospective examination of acute gastrointestinal lethality in rat bone marrow transplantation studies showed indication of a protective effect, with a dose modifying factor (DMF) of 1.06 (95% confidence interval: 0.99-1.12), but it should not be assumed that captopril will modulate radiation reactions in all tissues. Expand
Radiation pneumotoxicity in rats: modification by inhibitors of angiotensin converting enzyme.
TLDR
A novel application for ACE inhibitors in general, and for Captopril in particular, as modifiers of radiation pneumotoxicity are suggested. Expand
Captopril reduces collagen and mast cell and eosinophil accumulation in pig serum‐induced rat liver fibrosis
TLDR
Data from an experimental model produced by repeated injections of whole pig serum into the peritoneal cavity of rats may indicate a novel action of angiotensin‐converting enzyme inhibitor in general, and for captopril in particular, as drugs potentially capable of reducing eosinophils in fibrotic processes. Expand
Radiation nephropathy in rats and its modification by the angiotensin converting enzyme inhibitor enalapril.
TLDR
It is concluded that enalapril, when used preventively from the time of irradiation, has a beneficial effect only after high doses per fraction and at the early phases of renal radiation injury. Expand
Effects of genistein following fractionated lung irradiation in mice.
TLDR
Genistein at the dose levels used in this study partially reduced the extent of fibrosis developing in mouse lung caused by irradiation but gave minimal protection against pneumonitis and there was no evidence that genistein caused protection of small tumors growing in the lung. Expand
Treatment of radiation nephropathy with captopril.
TLDR
It is concluded that captopril therapy preserves kidney function, reduces proteinuria, and enhances survival in experimental radiation nephropathy. Expand
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References

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Radiation-induced pulmonary endothelial dysfunction in rats: modification by an inhibitor of angiotensin converting enzyme.
TLDR
The ACE inhibitor Captopril ameliorates radiation-induced pulmonary endothelial dysfunction in rats sacrificed 2 months postirradiation, suggesting a novel application for this class of compounds as injury-modifying agents in irradiated lung. Expand
The effect of Captopril on benign and malignant reactions in irradiated rat skin.
TLDR
Captopril, known to ameliorate acute lung damage in irradiated rats, also reduces chronic benign and malignant skin reactions in the radiation treatment field. Expand
Collagen accumulation in irradiated rat lung: modification by D-penicillamine.
The collagen antagonist D-penicillamine (10 mg/day, p.o.) significantly ameliorated radiation-induced hydroxyproline (HP) accumulation in the lungs of rats killed 3, 6, 9, or 12 months after a singleExpand
Radiation-induced endothelial dysfunction and fibrosis in rat lung: modification by the angiotensin converting enzyme inhibitor CL242817.
TLDR
The data suggest that the ability of ACE inhibitors to ameliorate radiation-induced pulmonary endothelial dysfunction is not unique to captopril, rather it is a therapeutic action shared by other members of this class of compounds. Expand
The effect of colchicine on the accumulation of hydroxyproline and on lung compliance after irradiation.
TLDR
It was found that collagen deposition can be reduced only if colchicine is injected when the lung collagen is being synthesized, namely around 90 days after irradiation with these doses. Expand
Prostacyclin and Thromboxane Production by Irradiated Rat Lung
The production of prostacyclin (PGI2) and thromboxane (TXA2) by irradiated rat lung and the concentration of these prostanoids in the bronchoalveolar lavage (BAL) fluid were measured in ratsExpand
Monocrotaline-Induced Pulmonary Fibrosis in Rats: Amelioration by Captopril and Penicillamine
TLDR
Hydxyproline data demonstrate that the ACE inhibitor Captropril exhibits antifibrotic activity in monocrotaline-treated rat lung, and penicillamine, known to inhibit radiation-induced lung injury, thus is shown to be effective in a second model of pulmonary fibrosis. Expand
Inhibition of vascular permeability changes in rats by captopril.
TLDR
The data suggest that captopril may have potent antiinflammatory activity through as yet undefined mechanisms. Expand
The ultrastructure of radiation injury in rat lung: modification by D-penicillamine.
TLDR
Penicillamine treatment produces a generalized inhibition of pathologic events such as collagen accumulation and arterial wall thickening, and acceleration of restorative processes such as revascularization andmore » collagen degradation. Expand
Late functional and biochemical changes in mouse lung after irradiation: differential effects of WR-2721.
TLDR
The data suggest that changes in breathing rate and deaths later than 9 months after whole lung irradiation may not be due to collagen accumulation in the lung, and protection of late lung damage measured from either lethality or breathing rate is not related to the prevention of lung fibrosis. Expand
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