Captopril enhances aminoglycoside nephrotoxicity in potassium-depleted rats.

  title={Captopril enhances aminoglycoside nephrotoxicity in potassium-depleted rats.},
  author={Paul E. Klotman and James Boatman and B D Volpp and Josephine D. Baker and William E. Yarger},
  journal={Kidney international},
  volume={28 2},
We demonstrated that potassium depletion significantly increased gentamicin nephrotoxicity in Sprague-Dawley rats (100 mg X kg-1 X day-1). To determine whether this enhanced toxicity was mediated by renin secretion, we evaluated the effect of a converting enzyme inhibitor in this model. When we administered the combination of captopril (100 mg X kg-1 X day-1) and gentamicin in potassium-depleted rats, we observed a surprising and significant adverse effect of this combination on the clearances… CONTINUE READING

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