Captopril decreases plasminogen activator inhibitor-1 in rats with ventilator-induced lung injury.

@article{Chen2008CaptoprilDP,
  title={Captopril decreases plasminogen activator inhibitor-1 in rats with ventilator-induced lung injury.},
  author={Chung-Ming Chen and H -N. Chou and Leng-fang Wang and Y. D. Lang},
  journal={Critical care medicine},
  year={2008},
  volume={36 6},
  pages={1880-5}
}
OBJECTIVE To test the hypotheses that high tidal-volume ventilation increases plasminogen activator inhibitor (PAI)-1, and the angiotensin-converting enzyme inhibitor, captopril (CAP), may attenuate these effects. SETTING University research facility. SUBJECTS Twenty adult male Sprague-Dawley rats. INTERVENTIONS All rats were randomized to receive two ventilation strategies for 2 h: 1) a high-volume zero positive end-expiratory pressure (PEEP) (HVZP) group at a tidal volume of 40 mL/kg, a… CONTINUE READING