Captopril and hypertension development in the SHR.

  title={Captopril and hypertension development in the SHR.},
  author={J. F. Giudicelli and Jean Louis Freslon and Sonya S. Glasson and Christine Richer},
  journal={Clinical and experimental hypertension},
  volume={2 6},
Captopril (100mg/kg) administered daily by gavage to young spontaneously hypertensive rats (SHRs) from their 6th to 20th weeks of age almost completely inhibited genetic hypertension development (GHD). This effect was correlated with an early and long-lasting limitation of the progressive increase in peripheral resistance which normally develops in SHRs during their growth. Heart rate, cardiac and systolic indexes remained unchanged, plasma renin concentration was significantly increased and… CONTINUE READING

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