Captopril--a potential free radical scavenger: inhibition of PMN NADPH oxidase.

  title={Captopril--a potential free radical scavenger: inhibition of PMN NADPH oxidase.},
  author={Terrance M. Egan and Joe O. Minta and K G Scrimgeour and Joel David Cooper},
  journal={Clinical and investigative medicine. Medecine clinique et experimentale},
  volume={11 5},
We postulated that Captopril may be capable of acting as a scavenger of free radicals, and performed in vitro studies using harvested human neutrophils. We studied the effect of Captopril on the reduction of Fe3+ cytochrome c by stimulated PMN's. Captopril acts as a reducing agent in this system, and is capable of reducing Fe3+ cytochrome c by itself. NADPH oxidase was harvested from PMA-stimulated human PMN's. Captopril inhibited the activity of this enzyme as assessed by the disappearance of… CONTINUE READING


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