Captopril: a new treatment for rheumatoid arthritis?

  title={Captopril: a new treatment for rheumatoid arthritis?},
  author={Mar{\'i}a Rodr{\'i}guez Mart{\'i}n and K. E. Surrall and Frank Mckenna and J. Scott Dixon and Howard A. Bird and Virginia F. Wright},
  volume={1 8390},
Captopril, an inhibitor of angiotensin converting enzyme, is prescribed for hypertension. Its molecular structure shares features with D-penicillamine, in that both agents contain a thiol group. In addition, captopril has immunosuppressant activity. Captopril was therefore considered a potential slow-acting drug for treating rheumatoid arthritis. In an open study 15 patients with active arthritis were treated with captopril and followed for 48 weeks. Two-thirds of the patients reported improved… CONTINUE READING


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