Capsule size of Cryptococcus neoformans: control and relationship to virulence.

@article{Dykstra1977CapsuleSO,
  title={Capsule size of Cryptococcus neoformans: control and relationship to virulence.},
  author={Mark A. Dykstra and Lawrence Friedman and Juneann W. Murphy},
  journal={Infection and immunity},
  year={1977},
  volume={16 1},
  pages={129-35}
}
Capsule size of five isolates of Cryptococcus neoformans was controlled by cultivation in media containing varying amounts of sugar. High concentrations of sugar (e.g., 16%) suppressed encapsulation whereas low concentrations (e.g., 1%) allowed maximal encapsulation. Suppression of capsule size was attributed at least in part to the increased osmolarity of the medium because a medium with low sugar concentration but having high osmolarity (by virtue of added sodium chloride) also produced cells… CONTINUE READING