Capsule production and growth phase influence binding of complement to Staphylococcus aureus.

@article{Cunnion2001CapsulePA,
  title={Capsule production and growth phase influence binding of complement to Staphylococcus aureus.},
  author={Kenji M Cunnion and Joseph Ching Hua Lee and Mike Frank},
  journal={Infection and immunity},
  year={2001},
  volume={69 11},
  pages={
          6796-803
        }
}
Complement-mediated opsonization of bacteria by C3 binding is an important component of the host innate immune system. Little information is available concerning the interaction between complement proteins and capsule type 5 and 8 Staphylococcus aureus strains, even though these isolates are responsible for approximately 70% of human staphylococcal infections. To investigate the importance of an intact complement pathway in an experimental staphylococcal infection, control and C3-depleted mice… CONTINUE READING

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