D avis et al. 1 report on the effectiveness and costeffectiveness of approaches to increase mammography screening among 1,181 women in Federally Qualified Health Centers (FQHCs) in Louisiana. The three arms evaluated were enhanced usual care (i.e., recommendation for and scheduling of mammogram), health literacy informed education (i.e., enhanced usual care plus educational materials), and health literary+nurse support (i.e., health literacy informed education plus nurse navigation). While all significantly increased mammography screening rates over baseline, the health literacy+nurse support arm was the most effective. Surprisingly, health literacy informed education was less effective than enhanced usual care, leading the authors to speculate that education to increase knowledge and awareness about breast cancer and mammography may not be necessary in this population, many of whom had previously received a mammogram. An important strength of this study is the inclusion of a cost-effectiveness analysis. The Community Preventive Services Task Force has identified types of interventions that successfully increase mammography screening. Previous research has demonstrated that women reporting a provider recommendation were significantly more likely to receive a mammogram. Further, studies suggest that patient navigation facilitates mammography screening, particularly among the traditionally medically underserved. To increase the application of this work, there may be opportunities for public health entities to implement innovative approaches to identify women who need screening services, encourage participation, and monitor results. Importantly, the authors note that the nurse support arm may not be feasible for lower resource clinics. The navigation activities described in this study may be successfully completed by lay and other health professionals at lower cost. Caution is warranted before determining that women do not still require education to increase knowledge and awareness about screening mammography—the need for education may vary by the population being served. Additional research is needed to identify and monitor additional barriers and facilitators to receipt of routine screening in this population, determine the individual-level and system-level characteristics of effective patient navigation programs, and demonstrate how electronic medical records can be used more effectively to track patients in safety-net clinics, hospitals, and systems.