Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors.

@article{Pien2009CapsidAP,
  title={Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors.},
  author={Gary C Pien and Etiena Basner-Tschakarjan and Daniel J. Hui and Ashley N. Mentlik and Jonathan D. Finn and Nicole C Hasbrouck and Shangzhen Zhou and Samuel L. Murphy and Marcela V Maus and Federico Mingozzi and Jordan S Orange and K. A. High},
  journal={The Journal of clinical investigation},
  year={2009},
  volume={119 6},
  pages={1688-95}
}
Adeno-associated virus (AAV) vectors are effective gene delivery vehicles mediating long-lasting transgene expression. Data from a clinical trial of AAV2-mediated hepatic transfer of the Factor IX gene (F9) into hemophilia B subjects suggests that CTL responses against AAV capsid can eliminate transduced hepatocytes and prevent long-term F9 expression. However, the capacity of hepatocytes to present AAV capsid-derived antigens has not been formally demonstrated, nor whether transduction by AAV… CONTINUE READING
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CD8(+) T-cell responses to adeno-associated virus capsid in humans

  • F Mingozzi
  • Nat. Med
  • 2007
Highly Influential
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