Capsid Serotype and Timing of Injection Determines AAV Transduction in the Neonatal Mice Brain

@inproceedings{Chakrabarty2013CapsidSA,
  title={Capsid Serotype and Timing of Injection Determines AAV Transduction in the Neonatal Mice Brain},
  author={Paramita Chakrabarty and Awilda M. Rosario and Pedro M. Rodr{\'i}guez Cruz and Zoe B. Siemienski and Carolina Ceballos-Diaz and Keith W. Crosby and Karen R Jansen and David R Borchelt and Ji-Yoen Kim and Joanna L. Jankowsky and Todd E Golde and Yona R Levites},
  booktitle={PloS one},
  year={2013}
}
Adeno-associated virus (AAV) mediated gene expression is a powerful tool for gene therapy and preclinical studies. A comprehensive analysis of CNS cell type tropism, expression levels and biodistribution of different capsid serotypes has not yet been undertaken in neonatal rodents. Our previous studies show that intracerebroventricular injection with AAV2/1 on neonatal day P0 results in widespread CNS expression but the biodistribution is limited if injected beyond neonatal day P1. To extend… CONTINUE READING