Capsiate, a nonpungent capsaicin-like compound, inhibits angiogenesis and vascular permeability via a direct inhibition of Src kinase activity.

@article{Pyun2008CapsiateAN,
  title={Capsiate, a nonpungent capsaicin-like compound, inhibits angiogenesis and vascular permeability via a direct inhibition of Src kinase activity.},
  author={Bo-Jeong Pyun and Sun Choi and Yoonji Lee and Tae-Woong Kim and Jeong-Ki Min and Yonghak Kim and Byung-Dong Kim and Jeong-Han Kim and Shyam Kishor Sah and Young-Myeong Kim and Young-Guen Kwon},
  journal={Cancer research},
  year={2008},
  volume={68 1},
  pages={227-35}
}
Capsiate, a nonpungent capsaicin analogue, and its dihydroderivative dihydrocapsiate are the major capsaicinoids of the nonpungent red pepper cultivar CH-19 Sweet. In this study, we report the biological actions and underlying molecular mechanisms of capsiate on angiogenesis and vascular permeability. In vitro, capsiate and dihydrocapsiate inhibited vascular endothelial growth factor (VEGF)-induced proliferation, chemotactic motility, and capillary-like tube formation of primary cultured human… CONTINUE READING

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