Capsaicin suppresses the migration of cholangiocarcinoma cells by down-regulating matrix metalloproteinase-9 expression via the AMPK–NF-κB signaling pathway

@article{Lee2014CapsaicinST,
  title={Capsaicin suppresses the migration of cholangiocarcinoma cells by down-regulating matrix metalloproteinase-9 expression via the AMPK–NF-κB signaling pathway},
  author={Gong-Rak Lee and Soo Hwa Jang and Chang Jae Kim and Ah-Ram Kim and Dong-Joon Yoon and Neung-Hwa Park and In-Seob Han},
  journal={Clinical & Experimental Metastasis},
  year={2014},
  volume={31},
  pages={897-907}
}
Cholangiocarcinoma is one of the most difficult malignancies to cure. An important prognostic factor is metastasis, which precludes curative surgical resection. Recent evidence shows that capsaicin has an inhibitory effect on cancer cell migration and invasion. Here, we investigated the molecular mechanism of the capsaicin-induced anti-migration and anti-invasion effects on HuCCT1 cholangiocarcinoma cells. Migration and invasion were significantly reduced in response to capsaicin. Capsaicin… CONTINUE READING
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Schematic illustration of the PCR-amplified fragment of the MMP-9 promoter

  • YJ Surh, SS Han, Keum YS et al Inhibitory effects of curcumin, capsaicin on phorbol ester-induced activation of Fig. 7 Caps Upper
  • Lower: ChIP assays were conducted using anti-NF…
  • 2014

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