Capsaicin stimulates the non-store-operated Ca2+ entry but inhibits the store-operated Ca2+ entry in neutrophils.

@article{Wang2005CapsaicinST,
  title={Capsaicin stimulates the non-store-operated Ca2+ entry but inhibits the store-operated Ca2+ entry in neutrophils.},
  author={Jih Pyang Wang and Chia-Shun Tseng and Shu-Ping Sun and Yu-San Chen and Chi-Ren Tsai and M F Hsu},
  journal={Toxicology and applied pharmacology},
  year={2005},
  volume={209 2},
  pages={134-44}
}
Rat neutrophils express the mRNA encoding for transient receptor potential (TRP) V1. However, capsaicin-stimulated [Ca2+]i elevation occurred only at high concentrations (> or = 100 microM). This response was substantially decreased in a Ca2+-free medium. Vanilloids displayed similar patterns of Ca2+ response with the rank order of potency as follows: scutigeral>resiniferatoxin>capsazepine>capsaicin=olvanil>isovelleral. Arachidonyl dopamine (AAD), an endogenous ligand for TRPV1, failed to… CONTINUE READING
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