Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes.

@article{Gram2007CapsaicinsensitiveSF,
  title={Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes.},
  author={Dorte Xenia Gram and Bo Ahr{\'e}n and Istv{\'a}n Nagy and Uffe Bang Olsen and Christian Lehn Brand and Frank Sundler and Ren{\'e} Tabanera and Ove Svendsen and Richard David Carr and P{\'e}ter S{\'a}ntha and Nils Wierup and Anker Jon Hansen},
  journal={The European journal of neuroscience},
  year={2007},
  volume={25 1},
  pages={213-23}
}
The system that regulates insulin secretion from beta-cells in the islet of Langerhans has a capsaicin-sensitive inhibitory component. As calcitonin gene-related peptide (CGRP)-expressing primary sensory fibers innervate the islets, and a major proportion of the CGRP-containing primary sensory neurons is sensitive to capsaicin, the islet-innervating sensory fibers may represent the capsaicin-sensitive inhibitory component. Here, we examined the expression of the capsaicin receptor, vanilloid… CONTINUE READING

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