Capsaicin provokes apoptosis and restricts benzo(a)pyrene induced lung tumorigenesis in Swiss albino mice.

@article{Anandakumar2013CapsaicinPA,
  title={Capsaicin provokes apoptosis and restricts benzo(a)pyrene induced lung tumorigenesis in Swiss albino mice.},
  author={P. Glorinthal K. Anandakumar and Sattu Kamaraj and Sundaram Jagan and Gopalakrishnan Ramakrishnan and Thiruvengadam Devaki},
  journal={International immunopharmacology},
  year={2013},
  volume={17 2},
  pages={
          254-9
        }
}
Capsaicin (CAP), a constituent of red chilli and red pepper is exposed to exert compelling anticarcinogenic effects. In the present study, we examined the anti-tumorigenic potential of CAP on benzo(a)pyrene-induced mice lung tumorigenesis by analyzing the markers of apoptosis. Intraperitoneal administration of CAP (10mg/kg body weight) to Swiss albino mice suppressed the development of lung carcinoma by amending the protein expressions of apoptotic regulators p53, Bcl-2, Bax and caspase-3. The… CONTINUE READING
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