Capsaicin prevents degeneration of dopamine neurons by inhibiting glial activation and oxidative stress in the MPTP model of Parkinson's disease

@inproceedings{Chung2017CapsaicinPD,
  title={Capsaicin prevents degeneration of dopamine neurons by inhibiting glial activation and oxidative stress in the MPTP model of Parkinson's disease},
  author={Young Cheul Chung and Jeong Y Baek and Sang Ryong Kim and Hyuk Wan Ko and Eugene Bok and Won-Ho Shin and So-Yoon Won and Byung Kwan Jin},
  booktitle={Experimental &Molecular Medicine},
  year={2017}
}
The effects of capsaicin (CAP), a transient receptor potential vanilloid subtype 1 (TRPV1) agonist, were determined on nigrostriatal dopamine (DA) neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson’s disease (PD). The results showed that TRPV1 activation by CAP rescued nigrostriatal DA neurons, enhanced striatal DA functions and improved behavioral recovery in MPTP-treated mice. CAP neuroprotection was associated with reduced expression of… CONTINUE READING
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