Capsaicin pretreatment does not inhibit the opioid withdrawal response in guinea-pigs.

  • L A Chahl
  • Published 1988 in European journal of pharmacology


The effects of capsaicin pretreatment on withdrawal responses of guinea-pig isolated ileum to [Met5]enkephalin (ME) and morphine and on the locomotor withdrawal response of guinea-pigs following a single dose of morphine, were investigated. In vitro treatment of ileum with capsaicin, 1.5 mumol/l for 1 h, did not significantly affect the response to washout… (More)


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