Capsaicin pretreatment attenuates chronic hypoxic pulmonary hypertension.

  title={Capsaicin pretreatment attenuates chronic hypoxic pulmonary hypertension.},
  author={Y L Lai and C. F. Chen and Claudia Chien and H L Shiao and Arthur A. Thacker and Hui Qi Zhang},
  journal={Respiration physiology},
  volume={99 2},
Capsaicin pretreatment was used to deplete tachykinins in order to study the role of tachykinins in chronic hypoxia-induced pulmonary hypertension. Forty three young Wistar rats weighing 235 +/- 4 g were randomly divided into four groups: control (n = 10); capsaicin pretreatment (n = 10); intermittent chronic hypoxia (n = 10); and capsaicin pretreatment + intermittent chronic hypoxia (n = 13). Control animals breathed room air. Rats in the capsaicin pretreatment groups were given capsaicin via… CONTINUE READING