Capsaicin presynaptically inhibits glutamate release through the activation of TRPV1 and calcineurin in the hippocampus of rats.

@article{Lu2017CapsaicinPI,
  title={Capsaicin presynaptically inhibits glutamate release through the activation of TRPV1 and calcineurin in the hippocampus of rats.},
  author={Cheng Wei Lu and Tzu Yu Lin and Ting Yang Hsie and Shu Kuei Huang and Su Jane Wang},
  journal={Food & function},
  year={2017},
  volume={8 5},
  pages={
          1859-1868
        }
}
  • Cheng Wei Lu, Tzu Yu Lin, +2 authors Su Jane Wang
  • Published 2017
  • Medicine, Chemistry
  • Food & function
  • Capsaicin is the major ingredient in hot peppers of the plant Capsicum genus with neuroprotective effects in several preclinical models; its effect on glutamate release has been investigated in the rat hippocampus using isolated nerve terminals (synaptosomes) and brain slices. In a synaptosomal preparation, capsaicin dose-dependently reduced 4-aminopyridine-evoked Ca2+-dependent glutamate release, with an IC50 of approximately 11 μM. This inhibition was blocked by capsazepin, an antagonist of… CONTINUE READING

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