Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist.

  title={Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist.},
  author={Y Kobayashi and Y Nakano and Masahiro Kizaki and K Hoshikuma and Yoshiaki Yokoo and Takeshi Kamiya},
  journal={Planta medica},
  volume={67 7},
Evodiamine, a major alkaloidal principle of Evodia fruits (Evodia rutaecarpa, Rutaceae), showed vanilloid receptor agonistic activities comparable to capsaicin. The Chinese literature refers to Evodia fruits as a "hot nature" herb. In spite of the similarities in the actions of evodiamine and capsaicin in vitro, evodiamine has no perceptible taste, including a peppery hot taste. Therefore, the effectiveness of evodiamine and the extract of Evodia fruits in preventing obesity on male C3H mice… 

Evodiamine and Its Role in Chronic Diseases.

The physicochemical properties of EVO are presented, and the EVO's functions and mechanisms of action in various chronic diseases are reviewed.

Subchronic oral toxicity of evodia fruit powder in rats.

Long-term effects of evodiamine on expressions of lipogenesis and lipolysis genes in mouse adipose and liver tissues.

Results showed that average daily weight gain and rectal temperature decreased significantly over time in a dose-dependent manner, and evodiamine could influence lipid metabolism through regulation of the expressions of its key genes, as well as reduce body heat and body weight.

Evodiamine: A Novel Anti-Cancer Alkaloid from Evodia rutaecarpa

Growing evidence demonstrates that evodiamine possesses anti-cancer activities both in vitro and in vivo by inhibiting proliferation, invasion and metastasis, inducing apoptosis of a variety of tumor cell lines.

Nematocidal Constituents from the Ethanol Extract of Evodia rutaecarpa Hort Unripe Fruits

The ethanol extract of Chinese medicinal herb, Evodia rutaecarpa Hort unripe fruits, was found to possess nematocidal activity against the root-knot nematodes, Meloidogyne incognita, during the

Partial Activation and Inhibition of TRPV1 Channels by Evodiamine and Rutaecarpine, Two Major Components of the Fruits of Evodia rutaecarpa.

Results showed that, although 1 and 2 can activate TRPV1, the maximum response was 3.5- or 9-fold lower than that of capsaicin, respectively, suggesting partial agonism.

Gastroprotective effect of fructus evodiae water extract on ethanol-induced gastric lesions in rats.

It is suggested that Fructus Evodiae water extract prevented ethanol-induced gastric mucosal lesions by strengthening the mucosal barrier integrity and increasing gastricucosal nitric oxide (NO) synthesis.

Pharmacological Actions of Multi-Target-Directed Evodiamine

The present review includes the pharmacokinetics and the detailed exploration of target-binding properties of evodiamine in an attempt to provide a direction for further multi-target drug design.



The bronchoconstrictive action of evodiamine, an indoloquinazoline alkaloid isolated from the fruits of Evodia rutaecarpa, on guinea-pig isolated bronchus: possible involvement on vanilloid receptors.

The results suggest that the evodiamine-induced contractile response of the bronchus could be attributed to the resultant tachykinin release from sensory neurons by binding of evodiumine to vanilloid receptors.

The positive inotropic and chronotropic effects of evodiamine and rutaecarpine, indoloquinazoline alkaloids isolated from the fruits of Evodia rutaecarpa, on the guinea-pig isolated right atria: possible involvement of vanilloid receptors.

The results suggest that the positive inotropic and chronotropic effects on the guinea-pig isolated right atria induced by both evodiamine and rutaecarpine could be attributed to their interaction with vanilloid receptors and the resultant release of CGRP, a cardiotonic neurotransmitter, from capsaicin-sensitive nerves as with Capsaicin.

Pharmacological properties of galenical preparation. XIV. Body temperature retaining effect of the Chinese traditional medicine, "goshuyu-to" and component crude drugs.

It is confirmed that the body temperature retaining effect occurred mainly with Evodia fruit alkaloid hydroxyevodiamine, and other component crude drugs exhibited no bodyTemperature retaining effect in this experiment system.

Effects of capsaicin and isothiocyanate on thermogenesis of interscapular brown adipose tissue in rats.

The administration of capsaicin or isothiocyanate activates BAT function in rats and increases significantly IBAT temperature, GDP binding, and mitochondrial oxygen consumption in IBAT.

Dietary effects on liver and muscle glycogen repletion in exhaustively exercised rats: energy composition and type of complex carbohydrates.

A high-carbohydrate diet is more effective than a high-fat diet for further glycogen repletion in liver and skeletal muscle and dextrin was revealed to be superior to starch as a carbohydrate source in tissue glycogenRepletion.