Capsaicin is beneficial to hyperlipidemia, oxidative stress, endothelial dysfunction, and atherosclerosis in Guinea pigs fed on a high-fat diet.

  title={Capsaicin is beneficial to hyperlipidemia, oxidative stress, endothelial dysfunction, and atherosclerosis in Guinea pigs fed on a high-fat diet.},
  author={Siyuan Yang and Lin Liu and L U Meng and Xuanyi Hu},
  journal={Chemico-biological interactions},

Antiobesity, Regulation of Lipid Metabolism, and Attenuation of Liver Oxidative Stress Effects of Hydroxy-α-sanshool Isolated from Zanthoxylum bungeanum on High-Fat Diet-Induced Hyperlipidemic Rats

Results revealed that HAS exerts antiobesity and hypolipidemic activities in HFD rats by reducing liver oxidative stress and thus could be considered as a potential candidate drug to cure or prevent obesity and hyperlipidemia.

Naringin Reverses High-Cholesterol Diet-Induced Vascular Dysfunction and Oxidative Stress in Rats via Regulating LOX-1 and NADPH Oxidase Subunit Expression

It is demonstrated that naringin treatment improves endothelium dysfunction in hypercholesterolaemic rats, at least partially by decreasing oxidative stress via downregulation of LOX-1 and NADPH oxidase.

Hawthorn fruit acid consumption attenuates hyperlipidemia-associated oxidative damage in rats

HFA administration can provide health benefits by counteracting the effects of hyperlipidemia caused by an HFD in the body, and the underlying mechanism of this event is closely related to the activation of the Nrf2/HO-1 signaling pathway.

Capsaicin Ameliorates High-Fat Diet-Induced Atherosclerosis in ApoE−/− Mice via Remodeling Gut Microbiota

Evidence is provided that gut microbiota plays a critical role in the anti-atherosclerosis effect of capsaicin and the role of depleting gut microbiota in the improvement of atherosclerosis is explored.

The protective effects of capsaicin on oxidative damage-induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats

As capsaicin regulates oxidative imbalance and attenuates histopathological alterations in the rat tissues, it may be preventing agents in TCDD toxicity.

Poria cocos polysaccharides reduces high‐fat diet‐induced arteriosclerosis in ApoE−/− mice by inhibiting inflammation

PCP intervenes in AS by reducing inflammatory factors and blood lipid levels and blocked the expression of matrix metalloproteinase 2 and intercellular adhesion molecule 1 proteins, which showed that PCP inhibited the serum inflammatory mediators and lipids increase.

The impact of capsaicinoids on APP processing in Alzheimer’s disease in SH-SY5Y cells

Pro-amyloidogenic properties also exist, enhancing Aβ-levels, likely restricting the potential use of capsaicinoids as therapeutic substances in Alzheimer’s disease.



Short‐term control of capsaicin on blood and oxidative stress of rats in vivo

It is hypothesized that capsaicin can be a potent antioxidant and aid in lowering LDL even when consumed for a short period and reduced oxidative stress measured as malondialdehyde in the liver, lung, kidney and muscle.

Modulation of lipopolysaccharide-induced oxidative stress by capsaicin

It is suggested that in the presence of mild systemic inflammation, acute capsaicin administration might alter oxidative status in some tissues and exert an anti-inflammatory effect.

Antioxidant and antiapoptotic effects of capsaicin against carbon tetrachloride-induced hepatotoxicity in rats

Capsaicin confers an appealing hepatoprotective effect which might be explained partially via diminishing the generation of MDA, induction of antioxidant systems and inhibition of active caspase-3.

Celastrus orbiculatus Thunb. ameliorates high-fat diet-induced non-alcoholic fatty liver disease in guinea pigs.

Results reveal that administration of COT effectively ameliorates high-fat diet-induced NAFLD in guinea pigs through decreasing hepatic lipid levels, suppressing oxidative stress and lowering NO and iNOS levels in liver.

Hyperlipidemic guinea pig model: mechanisms of triglyceride metabolism disorder and comparison to rat.

There are differences in triglyceride metabolism between the two species when fed high-fat diets, which may explain the differences in plasma and hepatic TG concentrations between guinea pigs and rats.

The effect of 4-week chilli supplementation on metabolic and arterial function in humans

Four weeks of regular chilli consumption has no obvious beneficial or harmful effects on metabolic parameters but may reduce resting heart rate and increase effective myocardial perfusion pressure time in men.

Capsaicin may have important potential for promoting vascular and metabolic health

In rodent studies, capsaicin-rich diets have shown favourable effects on atherosclerosis, metabolic syndrome, diabetes, obesity, non-alcoholic fatty liver, cardiac hypertrophy, hypertension and stroke risk and further clinical studies are needed to establish protocols that are tolerable for most patients, and to evaluate the potential of Capsaicin for promoting vascular and metabolic health.