Capsaicin is beneficial to hyperlipidemia, oxidative stress, endothelial dysfunction, and atherosclerosis in Guinea pigs fed on a high-fat diet.

@article{Yang2019CapsaicinIB,
  title={Capsaicin is beneficial to hyperlipidemia, oxidative stress, endothelial dysfunction, and atherosclerosis in Guinea pigs fed on a high-fat diet.},
  author={Siyuan Yang and Lin Liu and L U Meng and Xuanyi Hu},
  journal={Chemico-biological interactions},
  year={2019},
  volume={297},
  pages={
          1-7
        }
}

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Capsaicin Ameliorates High-Fat Diet-Induced Atherosclerosis in ApoE−/− Mice via Remodeling Gut Microbiota

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Poria cocos polysaccharides reduces high‐fat diet‐induced arteriosclerosis in ApoE−/− mice by inhibiting inflammation

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The impact of capsaicinoids on APP processing in Alzheimer’s disease in SH-SY5Y cells

Pro-amyloidogenic properties also exist, enhancing Aβ-levels, likely restricting the potential use of capsaicinoids as therapeutic substances in Alzheimer’s disease.

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It is hypothesized that capsaicin can be a potent antioxidant and aid in lowering LDL even when consumed for a short period and reduced oxidative stress measured as malondialdehyde in the liver, lung, kidney and muscle.

Modulation of lipopolysaccharide-induced oxidative stress by capsaicin

It is suggested that in the presence of mild systemic inflammation, acute capsaicin administration might alter oxidative status in some tissues and exert an anti-inflammatory effect.

Antioxidant and antiapoptotic effects of capsaicin against carbon tetrachloride-induced hepatotoxicity in rats

Capsaicin confers an appealing hepatoprotective effect which might be explained partially via diminishing the generation of MDA, induction of antioxidant systems and inhibition of active caspase-3.

Celastrus orbiculatus Thunb. ameliorates high-fat diet-induced non-alcoholic fatty liver disease in guinea pigs.

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Capsaicin may have important potential for promoting vascular and metabolic health

In rodent studies, capsaicin-rich diets have shown favourable effects on atherosclerosis, metabolic syndrome, diabetes, obesity, non-alcoholic fatty liver, cardiac hypertrophy, hypertension and stroke risk and further clinical studies are needed to establish protocols that are tolerable for most patients, and to evaluate the potential of Capsaicin for promoting vascular and metabolic health.
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