Capsaicin is beneficial to hyperlipidemia, oxidative stress, endothelial dysfunction, and atherosclerosis in Guinea pigs fed on a high-fat diet.

@article{Yang2019CapsaicinIB,
  title={Capsaicin is beneficial to hyperlipidemia, oxidative stress, endothelial dysfunction, and atherosclerosis in Guinea pigs fed on a high-fat diet.},
  author={Siyuan Yang and Lin Liu and L U Meng and Xuanyi Hu},
  journal={Chemico-biological interactions},
  year={2019},
  volume={297},
  pages={
          1-7
        }
}

Antiobesity, Regulation of Lipid Metabolism, and Attenuation of Liver Oxidative Stress Effects of Hydroxy-α-sanshool Isolated from Zanthoxylum bungeanum on High-Fat Diet-Induced Hyperlipidemic Rats

Results revealed that HAS exerts antiobesity and hypolipidemic activities in HFD rats by reducing liver oxidative stress and thus could be considered as a potential candidate drug to cure or prevent obesity and hyperlipidemia.

Naringin Reverses High-Cholesterol Diet-Induced Vascular Dysfunction and Oxidative Stress in Rats via Regulating LOX-1 and NADPH Oxidase Subunit Expression

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Hawthorn fruit acid consumption attenuates hyperlipidemia-associated oxidative damage in rats

HFA administration can provide health benefits by counteracting the effects of hyperlipidemia caused by an HFD in the body, and the underlying mechanism of this event is closely related to the activation of the Nrf2/HO-1 signaling pathway.

Capsaicin Ameliorates High-Fat Diet-Induced Atherosclerosis in ApoE−/− Mice via Remodeling Gut Microbiota

Evidence is provided that gut microbiota plays a critical role in the anti-atherosclerosis effect of capsaicin and the role of depleting gut microbiota in the improvement of atherosclerosis is explored.

The protective effects of capsaicin on oxidative damage-induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats

As capsaicin regulates oxidative imbalance and attenuates histopathological alterations in the rat tissues, it may be preventing agents in TCDD toxicity.

Poria cocos polysaccharides reduces high‐fat diet‐induced arteriosclerosis in ApoE−/− mice by inhibiting inflammation

PCP intervenes in AS by reducing inflammatory factors and blood lipid levels and blocked the expression of matrix metalloproteinase 2 and intercellular adhesion molecule 1 proteins, which showed that PCP inhibited the serum inflammatory mediators and lipids increase.

Lycium barbarum polysaccharides and capsaicin modulate inflammatory cytokines and colonic microbiota in colitis rats induced by dextran sulfate sodium

Treatments with LP and/or capsaicin ameliorated disease activity index scores, severity of colon distortion, and shrinkage of colon length in rats with DSS-induced colitis via anti- inflammation and modulation of colonic microbiota.

Dietary Capsaicin: A Spicy Way to Improve Cardio-Metabolic Health?

It is concluded that although a chili pepper-rich diet is associated with a reduced risk of dying due to cardiovascular disease, dietary capsaicin has no clear effect on blood glucose or lipid profiles, and the reduced mortality risk may reflect the beneficial action of digested Capsaicin on gut microbiota.

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It is hypothesized that capsaicin can be a potent antioxidant and aid in lowering LDL even when consumed for a short period and reduced oxidative stress measured as malondialdehyde in the liver, lung, kidney and muscle.

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In rodent studies, capsaicin-rich diets have shown favourable effects on atherosclerosis, metabolic syndrome, diabetes, obesity, non-alcoholic fatty liver, cardiac hypertrophy, hypertension and stroke risk and further clinical studies are needed to establish protocols that are tolerable for most patients, and to evaluate the potential of Capsaicin for promoting vascular and metabolic health.

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Systemic administration of VOA decreased blood pressure and heart rate in a dose-dependent manner in both normotensive as well as spontaneously hypertensive rats and indicated that VOA increased the expression of endothelium nitric oxide synthase.
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